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  • Title: Highly enantioselective iridium-catalyzed hydrogenation of α,β-unsaturated esters.
    Author: Li JQ, Quan X, Andersson PG.
    Journal: Chemistry; 2012 Aug 20; 18(34):10609-16. PubMed ID: 22807347.
    Abstract:
    α,β-Unsaturated esters have been employed as substrates in iridium-catalyzed asymmetric hydrogenation. Full conversions and good to excellent enantioselectivities (up to 99 % ee) were obtained for a broad range of substrates with both aromatic- and aliphatic substituents on the prochiral carbon. The hydrogenated products are highly useful as building blocks in the synthesis of a variety of natural products and pharmaceuticals.
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