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  • Title: A lateral flow biosensor for detection of single nucleotide polymorphism by circular strand displacement reaction.
    Author: Xiao Z, Lie P, Fang Z, Yu L, Chen J, Liu J, Ge C, Zhou X, Zeng L.
    Journal: Chem Commun (Camb); 2012 Sep 04; 48(68):8547-9. PubMed ID: 22810628.
    Abstract:
    A lateral flow biosensor for detection of single nucleotide polymorphism based on circular strand displacement reaction (CSDPR) has been developed. Taking advantage of high fidelity of T4 DNA ligase, signal amplification by CSDPR, and the optical properties of gold nanoparticles, this assay has reached a detection limit of 0.01 fM.
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