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  • Title: [Pulmonary transfer factor for carbon monoxide (TLco) in healthy children and in children with chronic lung diseases, measured with an improved rebreathing technique].
    Author: Friedrich U, Schuster J, Zimmermann T.
    Journal: Pneumologie; 1990 Oct; 44(10):1205-7. PubMed ID: 2281070.
    Abstract:
    TLco, FRC-He and IVC were tested in 86 subjects (5-29 years). 46 children were healthy, 21 patients had cystic fibrosis, 13 bronchial asthma and 6 allergic alveolitis. The test gas included 14% helium and 0.3% CO. The wash in time was 18 s, the measuring time 20 s. All children were measured at rest and in a sitting position. The rebreathing volume was 3/4 of the VC plus 300 ml additional volume. The results showed a good reproducibility. The TLco increases with age, height, weight and body surface area, the correlation with VC, FRC and TLC was better. A differentiation between healthy children and patients suffering from lung disease is possible. The clearest results were shown in the case of patients suffering from CF.
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