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  • Title: [Thoughts and exploration on pharmacokinetic study of herbal medicines based on metabonomics and complex network].
    Author: Xiang Z, Cai XJ, Zeng S.
    Journal: Yao Xue Xue Bao; 2012 May; 47(5):558-64. PubMed ID: 22811996.
    Abstract:
    The change of drug development pattern pushes the innovation of drug valuation methods. The pharmacokinetic research of traditional Chinese medicines (TCM) is an important part of TCM modernization and plays a key role in novel drug development of TCM. However, the research methods and techniques are in consistent with the specific characteristics of TCM, i.e., multiple-components is still in the infant. This review makes a brief summary of current pharmacokinetic exploration of TCM, metabonomics and complex network, and puts forward a new strategy based on complex network and metabonomics to study TCM pharmacokinetic in order to disclose the active components and mechanism of TCM.
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