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  • Title: Evaluation of the cytotoxic activity of some Brazilian medicinal plants.
    Author: Ribeiro SS, de Jesus AM, dos Anjos CS, da Silva TB, Santos AD, de Jesus JR, Andrade MS, Sampaio TS, Gomes WF, Alves PB, Carvalho AA, Pessoa C, de Moraes MO, Pinheiro ML, Prata AP, Blank AF, Silva-Mann R, Moraes VR, Costa EV, Nogueira PC, Bezerra DP.
    Journal: Planta Med; 2012 Sep; 78(14):1601-6. PubMed ID: 22814822.
    Abstract:
    Plants are promising sources of new bioactive compounds. The aim of this study was to investigate the cytotoxic potential of nine plants found in Brazil. The species studied were: Annona pickelii Diels (Annonaceae), Annona salzmannii A. DC. (Annonaceae), Guatteria blepharophylla Mart. (Annonaceae), Guatteria hispida (R. E. Fr.) Erkens & Maas (Annonaceae), Hancornia speciosa Gomes (Apocynaceae), Jatropha curcas L. (Euphorbiaceae), Kielmeyera rugosa Choisy (Clusiaceae), Lippia gracilis Schauer (Verbenaceae), and Hyptis calida Mart. Ex Benth (Lamiaceae). Different types of extractions from several parts of plants resulted in 43 extracts. Their cytotoxicity was tested against HCT-8 (colon carcinoma), MDA-MB-435 (melanoma), SF-295 (glioblastoma), and HL-60 (promielocitic leukemia) human tumor cell lines, using the thiazolyl blue test (MTT) assay. The active extracts were those obtained from G. blepharophylla, G. hispida, J. curcas, K. rugosa, and L. gracilis. In addition, seven compounds isolated from the active extracts were tested; among them, β-pinene found in G. hispida and one coumarin isolated from K. rugora showed weak cytotoxic activity. In summary, this manuscript contributes to the understanding of the potentialities of Brazilian plants as sources of new anticancer drugs.
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