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  • Title: Association of macrovascular complications of type 2 diabetes mellitus with serum magnesium levels.
    Author: Agrawal P, Arora S, Singh B, Manamalli A, Dolia PB.
    Journal: Diabetes Metab Syndr; 2011; 5(1):41-4. PubMed ID: 22814841.
    Abstract:
    BACKGROUND: Diabetes mellitus and its complications are a significant cause of morbidity and mortality worldwide. Micronutrients have been evaluated as potential preventive and therapeutic measures in diabetes. The present study evaluated serum magnesium levels in diabetic patients-uncomplicated and those with macrovascular complications. METHOD: This study was done on 150 subjects (60 normal, healthy controls and 90 diabetics). The 90 diabetic patients were selected in the following categories-30 patients without complications (Study Group I), 30 diabetic patients with coronary artery disease (Study Group II) and 30 diabetic patients with peripheral vascular disease (Study Group III). Plasma glucose, glycated hemoglobin and serum magnesium levels were estimated in all the patients. RESULTS: Fasting plasma glucose and glycated hemoglobin levels were significantly higher in all the 3 study groups as compared to the controls, however, serum magnesium levels were significantly lower (p<0.05). In diabetic patients with coronary atherosclerosis or peripheral vascular disease, a significant negative correlation was observed between serum magnesium and fasting plasma glucose and glycated hemoglobin indicating the role of hypomagnesemia in diabetic complications. CONCLUSION: Dietary supplementation with magnesium in addition to classical therapies for diabetes may help in prevention of diabetic complications.
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