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  • Title: Quantum dot-nucleic acid/aptamer bioconjugate-based fluorimetric biosensors.
    Author: Zhou D.
    Journal: Biochem Soc Trans; 2012 Aug; 40(4):635-9. PubMed ID: 22817707.
    Abstract:
    Over the last 10 years, fluorescent semiconductor QD (quantum dot)-biomolecule conjugates have emerged as a powerful new sensing platform showing great potential in a wide range of applications in biosensing, environmental monitoring and disease diagnosis. The present mini-review is a brief account of the recent developments in QD-NA (nucleic acid), particularly NA aptamer, conjugate-based biosensors using the FRET (Förster resonance energy transfer) readout mechanism. It starts with a brief introduction to the NA aptamer and QD-FRET, followed by example approaches to compact QD-DNA conjugates, target readout strategies and sensing performance, and concludes with challenges and outlook for the QD-NA/aptamer bioconjugate sensors.
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