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  • Title: Oral ethanol self-administration in inbred Roman high- and low-avoidance rats: gradual versus abrupt ethanol presentation.
    Author: Manzo L, Gómez MJ, Callejas-Aguilera JE, Fernández-Teruel A, Papini MR, Torres C.
    Journal: Physiol Behav; 2012 Dec 25; 108():1-5. PubMed ID: 22820388.
    Abstract:
    Outbred Roman high-avoidance rats are known to consume more ethanol than inbred Roman low-avoidance rats. To determine whether ethanol consumption in inbred strains could be modulated by experiential factors, preference for a target 10% ethanol concentration was tested after either the gradual introduction of ethanol in increasing concentrations or the abrupt introduction of the target concentration. Whereas high-avoidance rats consumed more ethanol at lower concentrations, consumption and preference for ethanol over water were not differential across strains and administration procedure (gradual vs. abrupt). At the 4% concentration, ethanol was preferred over water by Roman high-avoidance rats, but water was preferred over ethanol by Roman low-avoidance rats. Ethanol consumption and preference for a 10% concentration appear to be immune to modification by either the gradual or abrupt ethanol presentation.
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