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  • Title: Enantioselective titanium(III)-catalyzed reductive cyclization of ketonitriles.
    Author: Streuff J, Feurer M, Bichovski P, Frey G, Gellrich U.
    Journal: Angew Chem Int Ed Engl; 2012 Aug 20; 51(34):8661-4. PubMed ID: 22821705.
    Abstract:
    Reduction, please! The title reaction affords α-hydroxyketones, a common structural motif in biologically active natural products, in good yields and high enantioselectivities at room temperature. The commercially available ansa-titanocene 1 was found to be an efficient catalyst for this process, which presumably proceeds by addition of a ketyl radical to a nitrile.
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