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  • Title: Helios expression in FoxP3(+) T regulatory cells.
    Author: Elkord E, Al-Ramadi BK.
    Journal: Expert Opin Biol Ther; 2012 Nov; 12(11):1423-5. PubMed ID: 22827571.
    Abstract:
    Recent work debates the suitability of Helios, an Ikarios family transcription factor, as a marker of thymic-derived natural T regulatory cells. However, Helios expression could be of particular importance in cancer. We and others reported that the majority of peripheral and tumour-infiltrating FoxP3(+) Tregs expresses Helios. Additionally, recent observations indicate that FoxP3(+)Helios(+) Tregs possess more suppressive characteristics, as compared to FoxP3(+)Helios(-) Tregs.
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