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  • Title: Synthesis and antimicrobial activities of a novel series of heterocyclic α-aminophosphonates.
    Author: Abdel-Megeed MF, Badr BE, Azaam MM, El-Hiti GA.
    Journal: Arch Pharm (Weinheim); 2012 Oct; 345(10):784-9. PubMed ID: 22829337.
    Abstract:
    Two series of novel α-aminophosphonates having heterocyclic moieties were synthesized in high yields. The structures of the newly synthesized compounds were confirmed by their elemental analyses, IR, (1)H NMR and MS spectral data. These compounds were screened for their antibacterial activities against Escherichia coli (NCIM2065) as a Gram-negative bacterium, Bacillus subtilis (PC1219) and Staphylococcus aureus (ATCC25292) as Gram-positive bacteria, and Candida albicans and Saccharomyces cerevisiae as fungi. The minimum inhibitory concentrations (MICs) of the synthesized compounds show high antibacterial and antifungal activities at low concentrations (10-1000 µg/mL). Furthermore, their lethal doses indicated that such compounds are safe for use as antimicrobial agents.
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