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  • Title: Interaction of extracellular vesicles of Bacteroides gingivalis W50 with human polymorphonuclear leucocytes.
    Author: Kay HM, Birss AJ, Smalley JW.
    Journal: FEMS Microbiol Lett; 1990 Oct; 60(1-2):69-73. PubMed ID: 2283043.
    Abstract:
    The effects of B. gingivalis W50 extracellular vesicles (ECV) on neutrophil chemotaxis and viability were assessed and compared with those of whole cells and the extracellular non-dialysable soluble protein (EP) fraction. None of the fractions tested, including soluble fractions derived from cells and ECV by sonication, induced neutrophil chemotaxis. Only ECV and cells inhibited f-MLP-stimulated chemotaxis. ECV and cells were cytotoxic towards neutrophils. The cytotoxic response was time dependent. The soluble EP fraction did not influence cell viability.
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