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  • Title: Anti-platelet aggregation and vasorelaxing effects of the constituents of the rhizomes of Zingiber officinale.
    Author: Liao YR, Leu YL, Chan YY, Kuo PC, Wu TS.
    Journal: Molecules; 2012 Jul 26; 17(8):8928-37. PubMed ID: 22836212.
    Abstract:
    In the present study, the chemical investigation of the bioactive fractions of the rhizomes of Zingiber officinale has resulted in the identification of twenty-nine compounds including one new compound, O-methyldehydrogingerol. Some of the isolates were subjected into the evaluation of their antiplatelet aggregation and vasorelaxing bioactivities. Among the tested compounds, [6]-gingerol and [6]-shogaol exhibited potent anti-platelet aggregation bioactivity. In addition, [10]-gingerol inhibited the Ca²⁺-dependent contractions in high K⁺ medium. According to the results in the present research, the bioactivity of ginger could be related to the anti-platelet aggregation and vasorelaxing mechanism.
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