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  • Title: Cu(I)-catalyzed atom transfer radical cyclization of trichloroacetamides tethered to electron-deficient, -neutral, and -rich alkenes: synthesis of polyfunctionalized 2-azabicyclo[3.3.1]nonanes.
    Author: Diaba F, Martínez-Laporta A, Bonjoch J, Pereira A, Muñoz-Molina JM, Pérez PJ, Belderrain TR.
    Journal: Chem Commun (Camb); 2012 Sep 11; 48(70):8799-801. PubMed ID: 22836236.
    Abstract:
    A novel synthetic entry to 2-azabicyclo[3.3.1]nonanes based on a copper(I)-catalyzed intramolecular coupling of amino-tethered trichloroacetamides and unsaturated nitriles, esters and alkenes, as well as enol acetates, is described. A study of the reaction conditions and the scope of the process is reported.
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