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  • Title: Antitumor and immunomodulatory activity of water-soluble polysaccharide from Inonotus obliquus.
    Author: Fan L, Ding S, Ai L, Deng K.
    Journal: Carbohydr Polym; 2012 Oct 01; 90(2):870-4. PubMed ID: 22840014.
    Abstract:
    The medicinal mushroom Inonotus obliquus has been used as a folk remedy for a long time in Russia and East-European countries to treat gastrointestinal cancer, cardiovascular disease and diabetes. In our study, a water-soluble polysaccharide (ISP2a) was successfully purified from I. obliquus by DEAE-Sepharose CL-6B and Sepharose CL-6B column chromatography. In vivo ISP2a had not only shown antitumor activity, but also could significantly enhance the immune response of tumor-bearing mice. In addition, ISP2a significantly enhanced the lymphocyte proliferation and increased the production of TNF-α. Results of these studies demonstrated that ISP2a had a potential application as natural antitumor agent with immunomodulatory activity.
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