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  • Title: Screening α-glucosidase inhibitors from mulberry extracts via DOSY and relaxation-edited NNR.
    Author: Shang Q, Xiang JF, Tang YL.
    Journal: Talanta; 2012 Aug 15; 97():362-7. PubMed ID: 22841093.
    Abstract:
    Inhibition of the α-glucosidase activity is a therapeutic approach for diabetes. In this study, an effective strategy for screening α-glucosidase inhibitors based on Nuclear magnetic resonance (NMR) techniques was developed to screen and identify α-glucosidase inhibitors from Mulberry leaf extract. As a result, deoxynojirimycin, as a potential α-glucosidase inhibitor, was found. The study suggested that our strategy was a powerful tool for screening and identification of α-glucosidase inhibitors in complex samples. Furthermore the interaction between α-glucosidase and its inhibitor was studied by NMR.
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