These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: HRMAS NMR as a tool to study metabolic responses in heart clam Ruditapes decussatus exposed to Roundup®.
    Author: Hanana H, Simon G, Kervarec N, Mohammadou BA, Cérantola S.
    Journal: Talanta; 2012 Aug 15; 97():425-31. PubMed ID: 22841103.
    Abstract:
    The essence of this study was to investigate the metabolic responses of heart tissues of carpet-shell clam Ruditapes decussatus after exposure to two doses (0.2 and 1 g/L) of Roundup(®) during 24 and 72 h. The main metabolic changes after Roundup(®) exposure were related to disturbance in energy metabolism and metabolic biomarkers such as alanine, succinate, acetate and propionate, suggesting the occcurence of anaerobiosis and the impairment of oxydative metabolism. Results showed also that peak intensities of amino acids used as biomarker of anaerobiosis in molluscs are time and dose dependent. In the opposite, phosphoarginine and ATP level are dependent to Roundup(®) concentration rather than to the time of exposure. We suggest that changes in energy demands require adjustements in the forward arginine kinase reaction rate. Therefore, the results demonstrate the high applicability of HRMAS NMR to elucidate the mechanism of toxicity of Roundup(®). In addition, (31)P HRMAS NMR appeared to be an effective and simple method to follow bioaccumulation of Roundup(®) formulation.
    [Abstract] [Full Text] [Related] [New Search]