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  • Title: No harmful effect of mycophenolate mofetil on liver regeneration: an experimental study.
    Author: Demiray M, Kucuk HF, Yildirim M, Barisik NO.
    Journal: Transplant Proc; 2012; 44(6):1743-6. PubMed ID: 22841260.
    Abstract:
    AIM: The aim of this experimental study was to examine the effects of mycophenolate mofetil (MMF) on liver regeneration in a partial hepatectomy model. METHODS: Rats were divided into 3 groups immediately following partial liver resection: saline, controls intraperitoneally (MMF; Group 1); MMF (15 mg/kg/d; Group II), and MMF (30 mg/kg/d; Group III). On days 3 and 7 following liver resection we humanely killed half of the rats in each group to measure alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels and to evaluate Ki-67 using immunohistochemistry. We calculated liver regeneration rates. RESULTS: The difference between ALT levels on days 3 and 7 was not significantly different among the groups (P = .157; P = .292; P > .05, respectively). The AST levels were significantly different at 3 days (P = .018) but not 7 days (P = .385). The Ki-67 level were different among groups at day 3 (P = .002) but not at day 7 (P = .290). Liver regeneration rates were not different among the groups either at 3 or at 7 days (P = .264 and P = .925, respectively). CONCLUSION: MMF stimulates mitosis but its effect on regeneration is not clear. MMF appeared to show no adverse effects on liver regeneration.
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