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  • Title: Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA.
    Author: Williams C, Chen W, Lee CH, Yaeger D, Vyleta NP, Smith SM.
    Journal: Nat Neurosci; 2012 Sep; 15(9):1195-7. PubMed ID: 22842148.
    Abstract:
    Voltage-activated Ca(2+) channels (VACCs) mediate Ca(2+) influx to trigger action potential-evoked neurotransmitter release, but the mechanism by which Ca(2+) regulates spontaneous transmission is unclear. We found that VACCs are the major physiological triggers for spontaneous release at mouse neocortical inhibitory synapses. Moreover, despite the absence of a synchronizing action potential, we found that spontaneous fusion of a GABA-containing vesicle required the activation of multiple tightly coupled VACCs of variable type.
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