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  • Title: [The use of inhibitors of prostaglandin synthesis for the treatment of acute nephro-ureteral colic of lithiasic origin].
    Author: Chandeck Monteza K, Cerrud Cerrud L.
    Journal: Rev Med Panama; 1990 Sep; 15(3):215-20. PubMed ID: 2284452.
    Abstract:
    The authors treated eight patients with acute renal colic due to calculi, confirmed by intravenous pyelogram, with piroxicam (Feldene), an inhibitor of prostaglandin synthesis (IPS), given intramuscularly in an initial dose of 20 mg followed by 20 mg in 20 minutes. They analyze the analgesic effect, the state of hydratation and urinary specific gravity before the use of the drug. The authors review the pathophysiology of acute renal colic and its new pharmacotherapy as well as the literature on this entity. The purpose of their paper is to present a new, effective and economic treatment of renal colic, in an environment with limited availability of sophisticated laboratory tests in an emergency room setting and not having available intravenous preparations of IPS. Five of eight patients (62.5%) experienced complete relief with the first dose of 20 mg, and one required an additional dose of 20 mg (seven of eight on 75%). These findings suggest that IPS by the intramuscular route are useful for relief of renal colic.
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