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  • Title: [Interferon-producing activity of bone marrow cells treated with mRNA for interferon when transplanted to irradiated mice].
    Author: Orlova TG, Zhdanova LV, Mentkevich LM, Shcheglovitova ON, Solov'ev VD.
    Journal: Vopr Virusol; 1979; (5):541-4. PubMed ID: 228497.
    Abstract:
    Inoculation into irradiated (800--850 r) mice of syngeneic bone marrow cells treated with mRNA for interferon (mRNA-If) obtained from chick cells induced with UV-irradiated Newcastle disease virus was accompanied by the appearance in the blood of the animals of a substance with the properties of interferon, inhibiting the cytopathic effect of vesicular stomatitis virus in chick embryo cells but not in mouse L cells. Chicken interferon was detected in the blood of the experimental animals for 7--10 days after transplantation of mRNA-If-treated cells.
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