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  • Title: Primary cutaneous diffuse large B-cell lymphoma, leg type: diagnostic considerations.
    Author: Hristov AC.
    Journal: Arch Pathol Lab Med; 2012 Aug; 136(8):876-81. PubMed ID: 22849734.
    Abstract:
    CONTEXT: Primary cutaneous diffuse large B-cell lymphoma, leg type, may show features that overlap with other lymphomas. However, timely recognition of this entity can have important clinical and therapeutic implications. OBJECTIVE: To review the clinical, morphologic, and immunophenotypic characteristics of primary cutaneous diffuse large B-cell lymphoma, leg type, and juxtapose these features with other diagnostic considerations. In particular, other variants of primary cutaneous diffuse large B-cell lymphoma, as well as primary cutaneous follicle center lymphoma, will be reviewed. Additionally, systemic/extracutaneous lymphomas will be discussed, including diffuse large B-cell lymphoma, not otherwise specified, Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly, and lymphomatoid granulomatosis. DATA SOURCES: Relevant literature will be reviewed and key differentiating findings will be highlighted. CONCLUSIONS: Although primary cutaneous diffuse large B-cell lymphoma, leg type, may show aspects that overlap with other lymphomas, it can be distinguished from other entities in the differential diagnosis.
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