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  • Title: An evaluation of p16(INK4a) expression in cervical intraepithelial neoplasia specimens, including women with HIV-1.
    Author: Nicol AF, Golub JE, e Silva JR, Cunha CB, Amaro-Filho SM, Oliveira NS, Menezes W, Andrade CV, Russomano F, Tristão A, Grinsztejn B, Friedman RK, Oliveira MP, Pires A, Nuovo GJ.
    Journal: Mem Inst Oswaldo Cruz; 2012 Aug; 107(5):571-7. PubMed ID: 22850945.
    Abstract:
    Although several studies have evaluated the role of p16(INK4a) as a diagnostic marker of cervical intraepithelial neoplasia (CIN) and its association with disease progression, studies regarding the role of p16(INK4a) in human immunodeficiency virus (HIV)-infected patients remain scarce. The present study was designed to determine the potential utility of p16(INK4a) as a diagnostic marker for CIN and invasive cervical cancer in HIV-positive and negative cervical specimens. An immunohistochemical analysis of p16(INK4a) was performed in 326 cervical tissue microarray specimens. Performance indicators were calculated and compared using receiving operating characteristics curve (ROC)/area under the curve. In HIV-1-negative women, the percentage of cells that was positive for p16(INK4a) expression was significantly correlated with the severity of CIN (p < 0.0001). A ROC curve with a cut-off value of 55.28% resulted in a sensitivity of 89%, a specificity of 81%, a positive predictive value of 91% and a negative predictive value of 78%. HIV-seropositive women exhibited decreased expression of p16(INK4a) in CIN2-3 specimens compared with HIV-negative specimens (p = 0.031). The ROC data underscore the potential utility of p16(INK4a) under defined conditions as a diagnostic marker for CIN 2-3 staging and invasive cervical cancer. HIV-1 infection, however, is associated with relatively reduced p16(INK4a) expression in CIN 2-3.
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