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  • Title: [Pharmacokinetic parameters of prednisone and prednisolone in healthy volunteers].
    Author: Etienne SD, Vandermeersch V, Chosidow O, Vu-Thi-My-Le C, Godeau P, Diquet B, Herson S.
    Journal: Ann Med Interne (Paris); 1990; 141(6):507-11. PubMed ID: 2285202.
    Abstract:
    A cross-over, double-blind, randomized trial with 8 healthy volunteers was undertaken to compare prednisolone and prednisone pharmacokinetics after a single oral dose (1 mg/kg) of prednisone (Cortancyl) and prednisolone sodium metasulfobenzoate (Solupred). Maximum prednisolone concentrations measured after ingestion of prednisone are higher (535 +/- 32 ng/ml) and occur earlier than after taking prednisolone sodium metasulfobenzoate (198 +/- 114 ng/ml) (p less than 0.001). The areas under the curve are significantly larger after prednisone than after prednisolone sodium metasulfobenzoate (p less than 0.02). These findings suggest a decreased systemic availability of prednisolone after prednisolone sodium metasulfobenzoate (Solupred) administration and show, from a strictly pharmacokinetic point of view, that equimolar doses of prednisone and prednisolone sodium metasulfobenzoate are not equivalent therapies.
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