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  • Title: Central effects of octopamine administered into the lateral ventricle of rats.
    Author: Kleinrok Z, Jagiełło-Wójtowicz E, Szkilnik E.
    Journal: Acta Physiol Pol; 1979; 30(4):445-53. PubMed ID: 228526.
    Abstract:
    Central effects of octopamine administered into the lateral ventricle of rats. Acta physiol. pol., 1979, 30 (4): 445--453. Octopamine (100, 250 and 500 micrograms/rat i.v.c.) exerted a stimulating effect on the central nervous system in rats, which was evidenced by increased spontaneous and basal motor activity, increased exploratory activity in the free-field test, and also increased motor activity in reserpinised rats pretreated with alpha-MT or nialamide. Octopamine decreased the body temperature and prolonged the duration of hexobarbital-induced sleep, and increased amphetamine-induced hyperactivity. Locomotor agitation after octopamine injection was inhibited by phenoxybenzamine and yohimbine in a dose of 10 mg/kg i.p.
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