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  • Title: Pd-catalyzed benzylic C-H amidation with benzyl alcohols in water: a strategy to construct quinazolinones.
    Author: Hikawa H, Ino Y, Suzuki H, Yokoyama Y.
    Journal: J Org Chem; 2012 Aug 17; 77(16):7046-51. PubMed ID: 22852777.
    Abstract:
    A novel method for the synthesis of 4-phenylquinazolinones via a palladium-catalyzed domino reaction of o-aminobenzamides with benzyl alcohols is developed. This protocol involves N-benzylation, benzylic C-H amidation, and dehydrogenation in water, which may play an important role in the smooth generation of the (η(3)-benzyl)palladium species by activation of the hydroxyl group of the benzyl alcohol.
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