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  • Title: Fluorogenic assay of alkaline phosphatase activity based on the modulation of excited-state intramolecular proton transfer.
    Author: Park J, Helal A, Kim HS, Kim Y.
    Journal: Bioorg Med Chem Lett; 2012 Sep 01; 22(17):5541-4. PubMed ID: 22853994.
    Abstract:
    A new fluorogenic substrate 1, which enables the fast and quantitative analysis of alkaline phosphatase activity, has been developed. Selective enzymatic hydrolysis of 1 instantly generated fluorescent compound 2 in aqueous media, which undergo an excited-state intramolecular proton transfer process, resulting in a remarkable fluorescence turn-on signal with an unusually large Stokes shift.
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