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  • Title: Anti-epidermal growth factor receptor monoclonal antibodies as potential anti-cancer agents.
    Author: Mendelsohn J.
    Journal: J Steroid Biochem Mol Biol; 1990 Dec 20; 37(6):889-92. PubMed ID: 2285602.
    Abstract:
    The EGF receptor is a potential target for antitumor therapy, because it is expressed at high levels on many human tumor cells and appears to be involved in autocrine stimulation of cell growth in a number of experimental studies. Anti-EGF receptor MAbs, which block ligand binding, can prevent the growth in culture of cells that are stimulated by EGF or TGF-alpha. Growth of human tumor xenografts bearing high levels of EGF receptors is also inhibited. A Phase I trial in patients with squamous cell carcinoma of the lung has demonstrated the capacity of a single dose of 120 mg anti-EGF receptor MAb to localize in such tumors and to achieve saturating concentrations in the blood for more than 3 days, without causing toxicity.
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