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  • Title: Are epidemiologic cut-off values predictors of the in vivo efficacy of azoles in experimental aspergillosis?
    Author: Calvo E, Pastor FJ, Sutton DA, Fothergill AW, Rinaldi MG, Salas V, Guarro J.
    Journal: Diagn Microbiol Infect Dis; 2012 Oct; 74(2):158-65. PubMed ID: 22858549.
    Abstract:
    We tried to correlate the in vitro activity and the in vivo efficacy of voriconazole (VRC) and posaconazole (POS) against Aspergillus flavus and Aspergillus niger. The in vitro susceptibility of a large set of isolates was determined by broth microdilution and disk diffusion methods, while the in vivo efficacy was assessed in a murine model of disseminated infection. For A. flavus, VRC showed efficacy even for strains with MICs above the epidemiologic cutoff value (ECV) (1 μg/mL). For A. niger, VRC was ineffective against those strains for which the MIC was 1 dilution below the corresponding ECV (2 μg/mL). POS showed efficacy against all the strains of both species included in the study, although isolates with MICs > ECV were not tested.
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