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  • Title: Combination of metolazone and furosemide in the treatment of edema in the first month of life.
    Author: Cachero SD, Lofland G, Springate JE, Feld LG.
    Journal: Child Nephrol Urol; 1990; 10(3):161-3. PubMed ID: 2285924.
    Abstract:
    A combination of metolazone (0.2 mg/kg/day) and furosemide (4 mg/kg/day) was used in the treatment of a 2-week-old neonate who developed severe edema after cardiac surgery. The edema, which was initially responsive to furosemide, became resistant to high doses of this diuretic even with the concomitant use of ethacrynic acid. The addition of metolazone to furosemide induced prompt diuresis and natriuresis. This combination of diuretics can be helpful in the treatment of refractory edema in young infants.
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