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  • Title: Comparison of the effects of captopril and enalapril on oxyphenbutazone and ethanol-induced gastric lesions in rats.
    Author: D'Souza RS, Bhounsule SA, Dhume VG.
    Journal: Indian J Physiol Pharmacol; 1990 Jul; 34(3):206-8. PubMed ID: 2286425.
    Abstract:
    We have compared the effect of the converting enzyme inhibitors, captopril and enalapril, on two models of gastric ulcers, viz; ethanol and oxyphenbutazone-induced lesions in rats. Both captopril and enalapril did not affect ethanol-induced lesions. While captopril significantly protected against oxyphenbutazone-induced lesions, enalapril aggravated the lesions. This difference is probably due to the lack of the protective sulfhydryl group in the chemical structure of enalapril.
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