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  • Title: Ophiamides A-B, new potent urease inhibitory sphingolipids from Heliotropium ophioglossum.
    Author: Firdous S, Ansari NH, Fatima I, Malik A, Afza N, Iqbal L, Lateef M.
    Journal: Arch Pharm Res; 2012 Jul; 35(7):1133-7. PubMed ID: 22864734.
    Abstract:
    Ophiamides A (1) and B (2), two new sphingolipids have been isolated from the n-hexane subfraction of the MeOH extract of the whole plant of Heliotropium ophioglossum along with glycerol monopalmitate (3) and β-sitosterol 3-O-β-D: -glucoside (4) reported for the first time from this species. Their structures were elucidated by spectroscopic techniques including MS and 2D-NMR spectroscopy. Both the compounds 1 and 2 showed potent inhibitory activity against the enzyme urease.
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