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  • Title: Increased collagen prolyl hydroxylase activity in the aortic wall of rabbits exposed to chronic hypoxia.
    Author: Turto H, Lindy S, Uitto J, Helin P, Garbarsch C, Lorenzen IB.
    Journal: Atherosclerosis; 1979 Aug; 33(4):379-84. PubMed ID: 228678.
    Abstract:
    The activity of collagen prolyl hydroxylase in aortic wall was studied in rabbits exposed to chronic 10% ambient oxygen tension for 30 days. Prolyl hydroxylase in rabbit aorta was shown to be similar to the enzyme from other sources in that it required molecular oxygen, alpha-ketoglutarate, ferrous iron and ascorbate for its activity. The activity of prolyl hydroxylase was increased to 180% of controls in the intima-media samples from rabbits exposed to hypoxia. No atherosclerotic lesions could be seen in arteries of animals kept in chronic hypoxia. If the arteries of rabbits were injured with a single mechanical dilatation, the activity of prolyl hydroxylase increased more than 2-fold, as reported previously. The exposure of these animals to chronic hypoxia further elevated the prolyl hydroxylase activity.
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