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  • Title: Immunogenicity of a 23-valent pneumococcal polysaccharide vaccine among Mexican children.
    Author: Espinosa-Padilla SE, Murata C, Estrada-Parra S, Santos-Argumedo L, Mascareñas C, Franco-Paredes C, Espinosa-Rosales FJ.
    Journal: Arch Med Res; 2012 Jul; 43(5):402-5. PubMed ID: 22868187.
    Abstract:
    BACKGROUND AND AIMS: Streptococcus pneumoniae infection continues to be a major source of morbidity and mortality in children in Mexico. The aim of this study was to evaluate the immune response to six serotypes in children <5 years of age after immunization with a 23-valent pneumococcal polysaccharide vaccine. METHODS: A prospective study was conducted among children aged from 18 months to 4 years. Pre- and postvaccination titers for the serotypes selected in this project demonstrate a substantial response among all age groups. RESULTS: We identified mild adverse events in 62% of the participants in this study. No serious adverse events were reported during the study. CONCLUSIONS: Pneumococcal polysaccharide vaccine produced adequate immunogenicity in all age groups evaluated.
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