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  • Title: In vivo antioxidant activity of total flavonoids from indocalamus leaves in aging mice caused by D-galactose.
    Author: Jin SL, Yin YG.
    Journal: Food Chem Toxicol; 2012 Oct; 50(10):3814-8. PubMed ID: 22874925.
    Abstract:
    OBJECTIVE: The aim of this thesis is to explore antioxidant activity of total flavonoids extracted from indocalamus leaves. METHOD: Aging mice model was established by D-galactose induction. Three groups of mice were treated with total flavonoids extracted from indocalamus leaves at doses of 20, 40 and 80 mg/kg d bw respectively. The antioxidant status in the aging mice was measured by determining the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) and total anti-oxidant capability (T-AOC) in the serum and liver and malondialdehyde (MDA) content in the serum, liver and brain. RESULTS: Compared with control group, extracts of indocalamus leaves significantly enhanced activities of SOD, GSH-Px, CAT in the serum and liver, and decreased MDA content in the serum, liver and brain at the tested doses. CONCLUSION: Total flavonoids extracted from indocalamus leaves demonstrated the potent antioxidant activity.
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