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  • Title: Porphyrin-lipid stabilized gold nanoparticles for surface enhanced Raman scattering based imaging.
    Author: Tam NC, McVeigh PZ, MacDonald TD, Farhadi A, Wilson BC, Zheng G.
    Journal: Bioconjug Chem; 2012 Sep 19; 23(9):1726-30. PubMed ID: 22876736.
    Abstract:
    A porphyrin-phospholipid conjugate with quenched fluorescence was utilized to serve as both the Raman dye and a stabilizing, biocompatible surface coating agent on gold nanoparticles. Through simple synthesis and validation with spectroscopy and confocal microscopy, we show that this porphyrin-lipid stabilized AuNP is a novel SERS probe capable of cellular imaging. To date, this is the first use of porphyrin as a Raman reporter molecule for SERS based imaging.
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