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  • Title: [Effect of a synthetic somatostatin analogue with delayed action (SMS 201-995) on the biliary expenditure in a patient with an external biliary tract fistula].
    Author: Miranda-Ruiz R, Castañón-González J, Pérez Aldana C, Arias E, Díaz de León Ponce M, Zárate A.
    Journal: Rev Gastroenterol Mex; 1990; 55(2):67-9. PubMed ID: 2287871.
    Abstract:
    The effect of treatment with a long acting analogue of somatostatin (SMS 201-995) administered by subcutaneous route 165 micrograms every eight hours in a patient with a external biliary fistula is reported. There was a significant reduction of the daily fistula output during treatment when compared with the basal periods (p = 0.04), with an average decrease of 270 ml/day during the first period of treatment and 357 ml/day when the drug was administered the second time (p = 0.04). There where not changes in the chemical composition of the bile neither adverse side effects were observed during treatment. These results suggest that SMS 201-995 might be useful in the treatment of external biliary fistulas.
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