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  • Title: A case of paravertebral mediastinal chordoma without bone destruction.
    Author: Matsubayashi J, Sato E, Nomura M, Kakihana M, Uchida O, Saji H, Park J, Akata S, Ikeda N, Nagao T, Ishida T.
    Journal: Skeletal Radiol; 2012 Dec; 41(12):1641-4. PubMed ID: 22885720.
    Abstract:
    We report a unique case of mediastinal paravertebral chordoma without bone destruction in a 47-year-old Japanese woman. She was admitted to hospital after a tumor was incidentally detected on a chest radiograph. The tumor was located in the paravertebral region of the mediastinum and did not show any destruction of the thoracic vertebra radiologically. The tumor was clinically diagnosed as a benign neurogenic tumor and the tumor was easily removed surgically. Microscopically, the tumor mainly consisted of tumor cells with extensively vacuolated cytoplasm, arranged in cord- and nest-like fashion against a myxoid matrix background. Immunohistochemically, the tumor cells showed diffuse positivity for pancytokeratin (AE1/AE3) and vimentin. The tumor cell nuclei were positive for brachyury, which is a key transcription factor of notochordal development. These results confirmed the tumor to be an extraosseous chordoma in the paravertebral mediastinal region, which is an extremely rare location for a chordoma.
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