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  • Title: Reduced parietal connectivity with a premotor writing area in writer's cramp.
    Author: Delnooz CC, Helmich RC, Toni I, van de Warrenburg BP.
    Journal: Mov Disord; 2012 Sep 15; 27(11):1425-31. PubMed ID: 22886735.
    Abstract:
    Writer's cramp is a task-specific form of dystonia with symptoms characterized by abnormal movements and postures of the hand and arm evident only during writing. Its pathophysiology has been related to faulty sensorimotor integration, abnormal sensory processing, and impaired motor planning. Its symptoms might appear when the computational load of writing pushes a tonically altered circuit outside its operational range. Using resting-state fMRI, we tested whether writer's cramp patients have altered intrinsic functional connectivity in the premotor-parietal circuit. Sixteen patients with right-sided writer's cramp and 19 control subjects were studied. We show that writer's cramp patients have reduced connectivity between the superior parietal lobule and a dorsal precentral region that controls writing movements. This difference between patients and controls occurred in the absence of writing and only in the hemisphere contralateral to the affected hand. This finding adds a novel element to the pathophysiological substrate for writer's cramp, namely, task-independent alterations within a writing-related circuit.
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