These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Control of the transmembrane phospholipid distribution in eukaryotic cells by aminophospholipid translocase.
    Author: Devaux PF, Zachowski A, Morrot G, Cribier S, Fellmann P, Geldwerth D, Bitbol M, Herve P.
    Journal: Biotechnol Appl Biochem; 1990 Oct; 12(5):517-22. PubMed ID: 2288706.
    Abstract:
    The aminophospholipid translocase is a plasma membrane Mg2(+)-ATPase which selectively pumps the aminophospholipids (phosphatidylserine and phosphatidylethanolamine) from the outer to the inner monolayer in eukaryotic cells and is predominantly responsible for the asymmetric phospholipid distribution of the plasma membrane. Similar ATP-dependent transport of phospholipid takes place in some organelles such as chromaffin granules. On the other hand, the phospholipid flippase of rat liver endoplasmic reticulum does not require ATP and has a low lipid specificity. The biological implications of these phospholipid flippases are discussed.
    [Abstract] [Full Text] [Related] [New Search]