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  • Title: Mechanism of action of collagenase on the blood-brain barrier permeability. Increase of endothelial cell pinocytotic activity as shown with horse-radish peroxidase as a tracer.
    Author: Godeau G, Robert AM.
    Journal: Cell Biol Int Rep; 1979 Dec; 3(9):747-51. PubMed ID: 228873.
    Abstract:
    The ultrastructural mechanism of the protease induced blood-brain barrier permeability-increase was studied with horse-radish peroxidase as a tracer. After intravenous injection of collagenase or pronase, a significantly increased number of pinocytotic vesicles was found in brain capillary endothelial cells. alpha-Chymotrypsine did not exert such an action.
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