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  • Title: Cyclooxygenase-2-765G>C functional promoter polymorphism and its association with oral squamous cell carcinoma.
    Author: Lakshmi A, Muralidhar S, Kalyan Kumar C, Pavan Kumar A, Kalyana Chakravarthy P, Anjaneyulu V, Kaiser J.
    Journal: J Investig Clin Dent; 2012 Aug; 3(3):182-8. PubMed ID: 22887904.
    Abstract:
    AIM: Cyclooxygenase-2 is a key enzyme in the conversion of arachidonic acid to prostaglandins, and has critical role in the progression of several malignancies, including oral squamous cell carcinoma. METHODS: We designed a case-control study to evaluate the susceptibility of the functional -765G>C genetic variation in oral squamous cell carcinoma patients. Polymerase chain reaction-based restriction fragment length polymorphism analysis was used to determine the polymorphism in oral squamous cell carcinoma (n = 150) patients and healthy controls (n = 150). RESULTS: The genotype frequencies of cyclooxygenase-2 765G>G, 765G>C, and 765C>C were 73.3%, 18.66%, and 8.0% in the cancer patients, and 94.66%, 4% and 1.3% in the controls, respectively. The cyclooxygenase-2 GC and CC genotypes were significantly associated (P = 0.0003 and P = 0.01, respectively) with oral squamous cell carcinoma patients, when compared to the controls. The 765G>C genotypes were statistically significant, with habitual tobacco chewing and alcohol consumption + smoking (P = 0.05). CONCLUSIONS: This study highlights the genetic variant that might play a role in mediating susceptibility to oral squamous cell carcinoma in this population.
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