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  • Title: Effect of cyproterone acetate (CPA) on gonadal and adrenal function in men.
    Author: de la Torre B, Norén S, Hedman M, Diczfalusy E.
    Journal: Contraception; 1979 Oct; 20(4):377-96. PubMed ID: 228907.
    Abstract:
    Peripheral plasma was collected continuously from 10 healthy male subjects, aged 26-55 years, before and during the 3rd week of oral administration of daily doses of 20 mg of cyproterone acetate (CPA) to assess its effects on the circadian variation in levels of biologically active luteinizing hormone (LH), testosterone (T) and its dihydro metabolite (DT), 17-hydroxyprogesterone (17-P), androstenedione (A), pregnenolone (P), 17-hydroxypregnenolone (17-HP), dehydroepiandrosterone (DHEA), and cortisol (C). In addition to measuring these hormonal indexes, standardized dexamethasone-ACTH tests (with sulfurylated hormone complements) were carried out during Week 3 and before administration of CPA. CPA significantly suppressed LH (mean suppression, 39%), follicle stimulating hormone (66%), T (73%), DT (51%), 17-P (59%), and A (30%) in all 10 subjects, but it did not affect the circadian pattern. Levels of sulfurylated T (34%) and DT (35%) were also suppressed, according to the dexamethasone-ACTH test. No correlation was found between levels of LH and T; LH exhibited no circadian variation. Individual variation was great in C levels and P and 17-HP (delta 5 steroids) during ingestion of CPA. For example, C levels were increased in 2 subjects and diminished in 1. Similar changes in steroid levels were observed after the administration of dexamethasone and ACTH before and during the treatment period with CPA. However, dexamethasone induced an increase in LH and T levels pretreatment but not during treatment. On the other hand, sulfurylated T, DT, and DHEA were elevated by dexamethasone during CPA treatment, but not in pretreatment. ACTH increased significantly unconjugated DT levels during ingestion of CPA, but not in pretreatment.
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