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  • Title: Sudden onset agranulocytosis and hepatotoxicity after taking methimazole.
    Author: Yang J, Zhong J, Zhou LZ, Hong T, Xiao XH, Wen GB.
    Journal: Intern Med; 2012; 51(16):2189-92. PubMed ID: 22892501.
    Abstract:
    Agranulocytosis is a rare adverse effect of methimazole. The usual duration of treatment prior to the onset of agranulocytosis is approximately 1 to 4 months, and can be as long as 1 year. Agranulocytosis together with hepatotoxicity is an extremely rare idiosyncratic side effect of methimazole treatment. We present an unprecedented case of a Grave's disease patient who showed a strong reaction to methimazole with obvious agranulocytosis and hepatotoxicity which developed only six days after administration. This case, along with a literature review, is offered with the aim to increase the awareness of physicians of sudden onset agranulocytosis and hepatotoxicity from methimazole.
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