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  • Title: Ultrahigh-speed non-invasive widefield angiography.
    Author: Blatter C, Klein T, Grajciar B, Schmoll T, Wieser W, Andre R, Huber R, Leitgeb RA.
    Journal: J Biomed Opt; 2012 Jul; 17(7):070505. PubMed ID: 22894461.
    Abstract:
    Retinal and choroidal vascular imaging is an important diagnostic benefit for ocular diseases such as age-related macular degeneration. The current gold standard for vessel visualization is fluorescence angiography. We present a potential non-invasive alternative to image blood vessels based on functional Fourier domain optical coherence tomography (OCT). For OCT to compete with the field of view and resolution of angiography while maintaining motion artifacts to a minimum, ultrahigh-speed imaging has to be introduced. We employ Fourier domain mode locking swept source technology that offers high quality imaging at an A-scan rate of up to 1.68 MHz. We present retinal angiogram over ∼48  deg acquired in a few seconds in a single recording without the need of image stitching. OCT at 1060 nm allows for high penetration in the choroid and efficient separate characterization of the retinal and choroidal vascularization.
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