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  • Title: Probable hypersensitivity reaction to vancomycin associating rash, fever and neutropenia.
    Author: Dauby N, Fink W, Seyler L, Luce S, Nouwynck C, Tas S, Jacobs F.
    Journal: Acta Clin Belg; 2012; 67(3):226-8. PubMed ID: 22897075.
    Abstract:
    We describe the case of a 54-year old woman with breast cancer who was treated by vancomycin for febrile neutropenia due to a methicillin-resistant Staphyloccocus epidermidis infection of a surgically implanted catheter. She developed an hypersensitivity reaction to vancomycin associating neutropenia, fever, skin rash and elevated liver enzymes following re-challenge with vancomycin after having been misdiagnosed with septic thrombophlebitis. Following this re-challenge, neutrophils count fell dramatically but promptly resolved after cessation of vancomycin.
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