These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Electronic and vibrational optical activity of several peptides related to neurohypophyseal hormones: disulfide group conformation.
    Author: Pazderková M, Bednárová L, Dlouhá H, Flegel M, Lebl M, Hlaváček J, Setnička V, Urbanová M, Hynie S, Klenerová V, Baumruk V, Maloň P.
    Journal: Biopolymers; 2012 Nov; 97(11):923-32. PubMed ID: 22899367.
    Abstract:
    Electronic and vibrational optical activity of the set of neurohypophyseal hormones and their analogs was investigated to clarify the S-S bond solution conformation. The selected compounds include oxytocin (I), lysine vasopressin (II), arginine vasopressin (III), and their analogs (IV-IX), differing widely in their pharmacological properties. We have extended the already known electronic circular dichroism data by new information provided by vibrational circular dichroism (VCD) and Raman optical activity (ROA). The use of VCD brought additional details on three-dimensional structure of the chain reversal in the ring moiety and on its left handedness. Furthermore, Raman scattering and ROA allowed us to deduce the sense of the disulfide bond torsion.
    [Abstract] [Full Text] [Related] [New Search]