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  • Title: D-ring modified novel isosteviol derivatives: design, synthesis and cytotoxic activity evaluation.
    Author: Zhang T, Lu LH, Liu H, Wang JW, Wang RX, Zhang YX, Tao JC.
    Journal: Bioorg Med Chem Lett; 2012 Sep 15; 22(18):5827-32. PubMed ID: 22901386.
    Abstract:
    A series of polyhydric, amino alcohol and tricyclic derivatives were facilely synthesized by D-ring modification of isosteviol. These compounds were screened for their cytotoxic activities against four human tumor cell lines in vitro. Among them, the 15-α-aminomethyl-16-β-hydroxyl isosteviol 23 exhibits significant cytotoxicity superior to the positive control (cisplatin) against EC9706, PC-3 and HCT-116 cell lines.
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