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  • Title: [Inhalation therapy of antibiotics].
    Author: Noguchi Y, Taguchi M, Takasugi M, Sakamoto T, Matsumoto K.
    Journal: Nihon Kyobu Shikkan Gakkai Zasshi; 1990 Nov; 28(11):1432-5. PubMed ID: 2290226.
    Abstract:
    We produced experimental murine Klebsiella pneumoniae pneumonia by air-borne infection using exposure apparatus (LD50: 9.7 X 10 C.F.U./lung). The MIC value of cefazolin was 1.56 micrograms/ml, and that of gentamicin was 0.39 micrograms/ml. We treated this murine pneumonia with aerosolized antibiotics. The infected mice received inhalation of 50 mg (5 mg/ml), 100 mg (10 mg/ml), 200 mg (20 mg/ml) and 400 mg (40 mg/ml) gentamicin were alive. Survival rate of the infected mice treated with inhalation of 1000 mg (100 mg/ml) cefazolin was low, but that of them received inhalation of 500 mg (50 mg/ml) cefazolin was high. On the basis of these experiments it is suggested that aerosol of 50 mg/ml cefazolin gets to alveoli, and inhalation therapy of low level of cephems is proper for bacterial respiratory infections. Inhalation therapy of 50 mg/ml cephem for chronic bronchitis had a marked clinical effect. This proves that aerosol of cephem gets to infected bronchi.
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