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  • Title: [Biological effects of Gelatinol during artificial circulation].
    Author: Zinkevich OD, Medvedev VN, Safina NA, Kharrasov AF, Muginov MA.
    Journal: Klin Med (Mosk); 1990 Sep; 68(9):66-8. PubMed ID: 2290334.
    Abstract:
    The levels of plasma fibronectin (FN) were investigated in patients during heart surgery using artificial circulation. Plasma FN levels were assessed by electroimmunoassay (rocket immunoelectrophoresis) and bioassay (aggregation of gelatin-coated microparticles). The application of gelatinol in hemodilution++ composition led to the depletion of bioactive Fn from 140 to 0 micrograms/ml, whereas immunoreactive Fn levels were slightly elevated. The in vitro experiments have shown that gelatinol inhibits the aggregation of gelatinol-coated microparticles and chemiluminiscence of neutrophils, stimulated by gelatin-coated particles. Gelatinol elimination from hemodilution++ composition resulted in the reduction of postoperative mortality and accelerated tissue reparation.
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